Separation anxiety: Melatonin has been used in the treatment of separation anxiety in dogs, possibly due to its sedative effect. The lignans in the freshly-ground flax seeds may lower the estradiol levels that can increase in animals with adrenal disease. ![]() In addition to various herbal and homeopathic remedies to help patients with Cushing’s disease (as well as those with pre-Cushing’s elevations of ALP enzymes), melatonin may be added to the treatment plan along with flaxseed. Suggested actions of melatonin include the inhibition of certain enzymes needed for the conversion of one hormone to another for example, the inhibition of aromatase enzymes, which decreases androstenedione and testosterone conversion into estradiol and possibly the 21-hydroxylase enzyme (which would decrease cortisol levels.) Melatonin is currently used as part of the natural therapy regimen for some dogs with the pituitary form of Cushing’s disease, although its exact mechanism of action is unknown and its effectiveness varies among patients. It’s usually due to a benign tumor of the pituitary gland in the brain (some cases are caused by malignant tumors of the adrenal glands). dog or cat “Alzheimer’s”).Ĭushing’s disease: This condition involves an overproduction of hormones, most commonly cortisol, in the dog’s adrenal glands. This may be helpful for older animals that have trouble with normal sleep-wake cycles, typically seen in those with cognitive disorder (i.e. Sleep problems: Melatonin can induce restful sleep. In dogs and cats, melatonin has been prescribed for several conditions. As more research continues, it is likely additional uses of melatonin will be found. In people, it is also used for insomnia arising from many causes (lack of sleep, ADHD, beta-blocker blood pressure medication, etc.) sleep problems in autistic individuals dementia and Alzheimer’s disease depression chronic fatigue syndrome epilepsy numerous cancers as an anti-aging supplement and for weight loss.
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